Ubrolexin® - The smartly designed combination
Ubrolexin® is an original combination of two highly effective antibiotics: Cefalexin and Kanamycin.
Cefalexin is a 1st generation cephalosporin which is mainly active against Gram + pathogens including penicillinase-producing and non-penicillinase producing Staphylococcus aureus.
Kanamycin belongs to aminoglycosides’family and is mainly active against Gram - pathogens and against Staphylococcus aureus.
Cefalexin and Kanamycin work in a complementary way so that the antibiotic effect of Cefalexin is enhanced by Kanamycin and vice versa. This increases their joint ability to kill major mastitis organisms and so control disease. It’s called synergy.
The respective concentrations of Cefalexin and Kanamycin in the formulation are defined to achieve an enhanced and sustained bactericidal activity in the udder, even with an interval of 24 hours between treatments.
Why combining 2 antibiotics?
According to the practices in use in human medicine, combination therapy, with two or more antibiotics, can be recommended for the following reasons:
- To achieve synergy between antibiotics. Antibiotic synergism occurs when the effects of a combination of antibiotics is greater than the sum of the effects of the individual antibiotics.
- To broaden the antimicrobial spectrum.
- To prevent the emergence during treatment of strains resistant to one or more of the agents used.
Either targeted at a single pathogen or with a broad spectrum of antibacterial activity, combinations of antibiotics must aim at being complementary, getting an improved profile and superior activity over single compounds used alone.
